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Difference between Vitamin D3 and D2

Difference between Vitamin D3 and D2 blog post

Difference between Vitamin D3 and D2

Unveiling the Differences and Benefits of Vitamin D3 vs. Vitamin D2

Vitamin D is an important nutrient that plays a significant role in promoting calcium absorption, regulating bone growth, and supporting immune function. It exists in different forms, with vitamin D2 and vitamin D3 being the most common dietary variants. While both types contribute to meeting your vitamin D requirements, they exhibit notable differences in their sources and effectiveness. In this comprehensive blog post, we will delve into the distinctions between vitamin D2 and vitamin D3, shedding light on their benefits and helping you make an informed decision about which form may be more beneficial for your health.

Sources of Vitamin D3 and Vitamin D2:

Vitamin D3 primarily comes from animal-based sources, such as sun exposure and foods like fish oil and egg yolk. When your skin is exposed to sunlight or ultraviolet (UV) light, it produces vitamin D3. Additionally, it can be obtained through the consumption of fatty fish, liver, butter, and dietary supplements. On the other hand, vitamin D2 is predominantly sourced from plants. Certain mushrooms grown in UV light and fortified foods are the main sources of vitamin D2. While vitamin D3 is naturally present in animal-based products, vitamin D2 is commonly added to fortified foods due to its lower production cost.

Bio-availability and Effectiveness:

When it comes to bio availability and effectiveness, vitamin D3 holds an advantage over vitamin D2. Bio availability refers to the absorption and utilization of a nutrient by the body. Studies have shown that vitamin D3 is more efficiently absorbed by the body compared to vitamin D2. Once absorbed, vitamin D3 has a longer half-life, meaning it remains in circulation for an extended period, providing a sustained supply of this essential nutrient. Moreover, vitamin D3 has been found to be more effective at raising blood levels of calcifediol, the main circulating form of vitamin D, when compared to vitamin D2.

Vitamin D2 Supplements: Quality and Stability:

Some concerns have been raised about the quality and stability of vitamin D2 supplements. Research suggests that vitamin D2 may be more sensitive to humidity and temperature fluctuations, making it more prone to degradation over time. However, it is important to note that no studies have specifically examined the stability of oil-based vitamin D2 supplements. Currently, there is insufficient evidence to conclude that the quality of vitamin D2 supplements is significantly compromised. Proper storage, such as keeping the supplements in a closed container at room temperature, in a dry place, and away from direct sunlight, can help maintain their integrity.

Improving Your Vitamin D Status:

To improve your vitamin D status, several strategies can be implemented. Consuming foods rich in vitamin D, such as oily fish, fish oil supplements like cod liver oil, and egg yolk, and fortified products like milk and orange juice, can help increase your vitamin D levels. Additionally, spending time outdoors, particularly in the sun, allows your skin to produce vitamin D3 naturally. However, it is essential to strike a balance and avoid excessive sun exposure without sunscreen, as it can increase the risk of sunburn and skin cancer. If necessary, supplementation with vitamin D3 is recommended, with doses within the safe upper intake level of 4,000 IU (100 micrograms) per day for adults.

Choosing the Right Vitamin D Form:

Selecting the appropriate vitamin D form depends on various factors, including dietary preferences, lifestyle, and individual health needs. For individuals consuming animal-based products, vitamin D3 from sources like fish oil and egg yolk can be an excellent option due to its superior bioavailability and effectiveness. However, for those following a vegan or vegetarian lifestyle, obtaining vitamin D2 from UV-exposed mushrooms or plant-based vitamin D3 supplements derived from algae and lichen is a suitable alternative. It is advisable to consult with a healthcare professional or registered dietitian to determine the most appropriate form and dosage of vitamin D for your specific needs.


Vitamin D is a vital nutrient that supports numerous bodily functions, and obtaining adequate levels is crucial for maintaining optimal health. While both vitamin D2 and vitamin D3 contribute to meeting your vitamin D requirements, there are distinct differences between the two forms. Vitamin D3, primarily derived from animal-based sources, exhibits superior bio availability and effectiveness at raising blood levels of calcifediol. However, for those following a plant-based diet, vitamin D2 obtained from UV-exposed mushrooms or plant-based vitamin D3 supplements can be an effective alternative. Ultimately, the choice of vitamin D form should be based on individual circumstances and preferences, with guidance from healthcare professionals to ensure optimal vitamin D status and overall well-being.

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